Ceftriaxone sodium CAS#104376-79-6

Ceftriaxone sodium CAS#104376-79-6

Basic Information

Third-Generation Broad-Spectrum Antibiotic: Ceftriaxone is a third-generation cephalosporin with broad-spectrum antibacterial activity against a wide range of pathogens.


Effective Bacterial Cell Wall Inhibition: It works by disrupting the synthesis of the peptidoglycan layer in bacterial cell walls, effectively inhibiting bacterial survival and growth.


Neuroprotective Support Function: Ceftriaxone has been shown to increase excitatory amino acid transporter-2 (EAAT2) pump expression in the central nervous system.


Reduction of Glutamatergic Toxicity: It helps reduce glutamatergic toxicity in both in vitro and in vivo models, supporting its value in neurological research applications.


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product description

Product Description of Ceftriaxone Sodium CAS#104376-79-6

Ceftriaxone is a third-generation, broad-spectrum cephalosporin antibiotic that works by disrupting the synthesis of the peptidoglycan layer in bacterial cell walls, effectively inhibiting bacterial growth.

In addition to its antibacterial activity, ceftriaxone has been shown to enhance excitatory amino acid transporter-2 (EAAT2) expression in the central nervous system and reduce glutamatergic toxicity in both in vitro and in vivo models, highlighting its potential value in neurological research applications.


Product Application of Ceftriaxone Sodium CAS#104376-79-6

Ceftriaxone sodium (CAS#104376-79-6) belongs to the third-generation cephalosporin antibiotics. It exerts its bactericidal effect by inhibiting the synthesis of bacterial cell walls, thereby effectively killing microorganisms. It features a broad antibacterial spectrum and high stability, making it suitable for the treatment of susceptible bacterial infections in multiple systems, including the respiratory tract, urinary tract, abdominal cavity, and pelvic cavity.


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Product Information

Parameters

Melting point236 °C
alphaD25 -165° (c = 1 in water) (calc for water-free substance)
refractive index-160 ° (C=1, H2O)
storage temp.Keep in dark place,Inert atmosphere,2-8°C
solubilityH2O: soluble50mg/mL
pka~3 (COOH), 3.2 (NH3+), 4.1 (enolic OH)
formpowder or crystals
colorWhite to Off-White
Water SolubilityFreely soluble in water
InChIKeyFDRNWTJTHBSPMW-BBJOQENWSA-L


Safety Information


Hazard CodesXn
Risk Statements36/37/38-42/43
Safety Statements26-36-45-37-24-22
WGK Germany1
RTECSXI0368800
HS Code29349990
ToxicityLD50 in male, female, mice, rats (mg/kg): 3000, 2800, 2175, 2175 i.v.; >10000 all species orally; >5000 all species s.c. (Teelman)
ProviderLanguage
SigmaAldrichEnglish


Ceftriaxone sodium Usage And Synthesis


DescriptionCeftriaxone is a third-generation, broad-spectrum cephalosporin antibiotic that disrupts the synthesis of the peptidoglycan layer of bacterial cell walls. It has been shown to increase excitatory amino acid transporter-2 pump expression in the central nervous system and to reduce glutamatergic toxicity in both in vitro and in vivo models.
Chemical PropertiesWhite Crystalline Solid
Usesantipsychotic
UsesA potentially useful antibacterial agent for proteomics research.
UsesAn antibacterial, a third-generation cephalosporin.
DefinitionChEBI: Ceftriaxone disodium salt hemiheptahydrate is a cephalosporin.
Brand nameRocephin (Roche).
Biological Activityβ -lactam antibiotic. Displays neuroprotective activity in vivo via upregulation and increased activity of the EAAT2 glutamate transporter.


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FAQ

1. What kind of company is Bohai New Materials?
Bohai New Materials (Tianjin) Co., Ltd. is a foreign trade company specializing in the international trade of chemical products, located in the Binhai New Area of ​​Tianjin. Leveraging the strategic location of Tianjin Port, the company provides one-stop procurement and export services to global clients for a wide range of products, including plastic resins, basic chemical raw materials, fine chemicals, chemical fiber raw materials, and inorganic chemicals.


2. Which markets does the company serve?
Our products are primarily exported to Southeast Asia (Vietnam, Thailand, Indonesia, Malaysia), the Middle East (UAE, Saudi Arabia), Africa (Nigeria, Kenya), as well as Europe and the Americas.


3. Does the company have the qualifications to export hazardous chemicals?
Yes. We hold a valid license for the operation of hazardous chemicals and are well-versed in the export declaration, packaging, documentation, and transportation requirements for various types of hazardous goods. We are capable of handling the export of Class 3, Class 5, Class 8, and Class 9 hazardous chemicals.


4. What are the company's main products?
Our core product portfolio includes:
Plastic resins: PP, PE, PVC, ABS, PC, POM, etc.
Basic chemical raw materials: Soda ash, caustic soda, titanium dioxide, methanol, styrene, ethylene glycol, PTA, etc.
Fine chemicals: Pharmaceutical intermediates, pesticide intermediates, chemical additives, solvents, surfactants.
Chemical fiber raw materials: Polyester filament, polyester staple fiber, polyester chips (PET).
Inorganic chemicals: Calcium carbonate, talc powder, sodium sulfate, calcium chloride, magnesium chloride, etc.
Others: Paraffin wax, white oil, petroleum jelly (Vaseline), rubber, water treatment chemicals, etc.
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