Paclitaxel CAS#33069-62-4

Paclitaxel CAS#33069-62-4

Basic Information

Paclitaxel promotes microtubule polymerization and stabilizes polymerized microtubules, a unique mechanism among known drugs.


It specifically binds to polymerized microtubules without affecting unpolymerized tubulin dimers.


Paclitaxel interferes with cellular functions by causing microtubule accumulation, effectively blocking cell division during mitosis.


Clinically effective for ovarian and breast cancer, with additional therapeutic effects on lung cancer, colorectal cancer, melanoma, head and neck cancer, lymphoma, and brain tumors.



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Product Description of Paclitaxel CAS#33069-62-4

Paclitaxel is a diterpene extracted from yew bark. It uniquely promotes and stabilizes microtubule polymerization, binding only to formed microtubules. It disrupts cell division and arrests mitosis. Clinically, it is mainly used for ovarian and breast cancers, and also effective against lung, colorectal, melanoma, lymphoma and other malignancies.


Product Application of Paclitaxel CAS#33069-62-4

Paclitaxel is a natural broad-spectrum anticancer drug mainly for metastatic breast and ovarian cancers. It binds β-tubulin to stabilize microtubules, block depolymerization and arrest cell cycle at G2/M phase to suppress mitosis. It also acts effectively on human endothelial cells with low IC50 value.

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Product Information

Parameters


Melting point213 °C (dec.)(lit.)
alphaD20 -49° (methanol)
Boiling point774.66°C (rough estimate)
density0.2
refractive index-49 ° (C=1, MeOH)
Fp9℃
storage temp.2-8°C
solubilitymethanol: 50 mg/mL, clear, colorless
formpowder
pka11.90±0.20(Predicted)
colorwhite
Water Solubility0.3mg/L(37 ºC)
λmax227nm(MeOH)(lit.)
Merck146982
BRN1420457
Stability:Stable. Incompatible with strong oxidizing agents. Combustible.
InChIKeyRCINICONZNJXQF-MZXODVADSA-N
LogP3.950 (est)
CAS DataBase Reference33069-62-4(CAS DataBase Reference)
EPA Substance Registry SystemPaclitaxel (33069-62-4)


Safety Information


Hazard CodesXn
Risk Statements37/38-41-42/43-62-68-40-48-20/21/22-68/20/21/22
Safety Statements22-26-36/37/39-45
RIDADR1544
WGK Germany3
RTECSDA8340700
F45951
HazardClass6.1(b)
PackingGroupIII
HS Code29329990
Hazardous Substances Data33069-62-4(Hazardous Substances Data)
ToxicityLD50 intraperitoneal in mouse: 128mg/kg

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FAQ

1. What kind of company is Bohai New Materials?
Bohai New Materials (Tianjin) Co., Ltd. is a foreign trade company specializing in the international trade of chemical products, located in the Binhai New Area of ​​Tianjin. Leveraging the strategic location of Tianjin Port, the company provides one-stop procurement and export services to global clients for a wide range of products, including plastic resins, basic chemical raw materials, fine chemicals, chemical fiber raw materials, and inorganic chemicals.


2. Which markets does the company serve?
Our products are primarily exported to Southeast Asia (Vietnam, Thailand, Indonesia, Malaysia), the Middle East (UAE, Saudi Arabia), Africa (Nigeria, Kenya), as well as Europe and the Americas.


3. Does the company have the qualifications to export hazardous chemicals?
Yes. We hold a valid license for the operation of hazardous chemicals and are well-versed in the export declaration, packaging, documentation, and transportation requirements for various types of hazardous goods. We are capable of handling the export of Class 3, Class 5, Class 8, and Class 9 hazardous chemicals.


4. What are the company's main products?
Our core product portfolio includes:
Plastic resins: PP, PE, PVC, ABS, PC, POM, etc.
Basic chemical raw materials: Soda ash, caustic soda, titanium dioxide, methanol, styrene, ethylene glycol, PTA, etc.
Fine chemicals: Pharmaceutical intermediates, pesticide intermediates, chemical additives, solvents, surfactants.
Chemical fiber raw materials: Polyester filament, polyester staple fiber, polyester chips (PET).
Inorganic chemicals: Calcium carbonate, talc powder, sodium sulfate, calcium chloride, magnesium chloride, etc.
Others: Paraffin wax, white oil, petroleum jelly (Vaseline), rubber, water treatment chemicals, etc.
If you have specific product requirements, please feel free to contact us; we will quickly source high-quality products to meet your needs.


5. How can I obtain a product quote? What information is required?
You can contact us via our official website, by phone, or by email. To ensure a quick and accurate quote, please provide the following details: product name and specifications, target purchase quantity, destination port, and desired delivery time. Please also inform us of any special packaging or testing requirements.

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