Methyl acetoacetate CAS#105-45-3

Methyl acetoacetate CAS#105-45-3

Basic Information

Versatile Synthetic Reagent: Widely used in pharmaceutical synthesis and various organic reactions.


Key Role in Named Reactions: Participates in the Biginelli reaction, enabling the formation of valuable dihydropyrimidinone compounds.


Broad Derivative Formation: Supports the synthesis of diverse compounds such as pyrazole, pyrimidine, and coumarin derivatives.


Flexible Chemical Functionality: Suitable for producing α-substituted acetoacetic esters and cyclic structures, enhancing application versatility.



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product description

Product Description of Methyl acetoacetate CAS#105-45-3

Methyl acetoacetate is a chemical reagent widely used in pharmaceutical synthesis. It participates in the Biginelli reaction, enabling the formation of compounds such as dihydropyrimidinones. In addition, methyl acetoacetate (MAA) is utilized in the preparation of α-substituted acetoacetic esters and various cyclic compounds, including pyrazole, pyrimidine, and coumarin derivatives.


Product Application of Methyl acetoacetate CAS#105-45-3

Methyl acetoacetate (MAA) is used in a variety of applications. It serves as a chemical reagent in organic synthesis and can also function as a solvent for cellulose ethers. It is utilized as an intermediate in the preparation of organic compounds, including the synthesis of nifedipine. In addition, it is applied as a food additive, acting as an amine-protecting agent for synthetic sweeteners. MAA is also used as a pharmaceutical raw material in the production of antibiotics.


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Product Information

Parameters


Melting point-80 °C (lit.)
Boiling point169-170 °C/70 mmHg (lit.)
density1.076 g/mL at 25 °C (lit.)
vapor density4 (vs air)
vapor pressure1 hPa (20 °C)
refractive indexn20/D 1.419(lit.)
Fp158 °F
storage temp.2-8°C
solubility460 g/L (20°C)
pka10.67±0.46(Predicted)
formLiquid
colorAPHA: ≤20
Odorat 100.00 %. fresh fruity citrus green
PH3.8 (863g/l, H2O, 20℃)
Odor Typefruity
explosive limit1.3-14.2%(V)
Water Solubility460 g/L (20 ºC)
Merck146009
BRN506727
Cosmetics Ingredients FunctionsPERFUMING
InChI1S/C5H8O3/c1-4(6)3-5(7)8-2/h3H2,1-2H3
InChIKeyWRQNANDWMGAFTP-UHFFFAOYSA-N
SMILESCOC(=O)CC(C)=O
LogP0.185 (est)
CAS DataBase Reference105-45-3(CAS DataBase Reference)
NIST Chemistry ReferenceButanoic acid, 3-oxo-, methyl ester(105-45-3)
EPA Substance Registry SystemMethyl acetoacetate (105-45-3)


Safety Information


Hazard CodesXi
Risk Statements36
Safety Statements26
RIDADRNA1993
WGK Germany1
RTECSAK5775000
Autoignition Temperature536 °F
TSCATSCA listed
HazardClassCBL
HS Code29183000
Storage Class10 - Combustible liquids
Hazard ClassificationsEye Dam. 1
Hazardous Substances Data105-45-3(Hazardous Substances Data)
ToxicityLD50 orally in rats: 3.0 g/kg (Smyth, Carpenter)


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FAQ

1. What kind of company is Bohai New Materials?
Bohai New Materials (Tianjin) Co., Ltd. is a foreign trade company specializing in the international trade of chemical products, located in the Binhai New Area of ​​Tianjin. Leveraging the strategic location of Tianjin Port, the company provides one-stop procurement and export services to global clients for a wide range of products, including plastic resins, basic chemical raw materials, fine chemicals, chemical fiber raw materials, and inorganic chemicals.


2. Which markets does the company serve?
Our products are primarily exported to Southeast Asia (Vietnam, Thailand, Indonesia, Malaysia), the Middle East (UAE, Saudi Arabia), Africa (Nigeria, Kenya), as well as Europe and the Americas.


3. Does the company have the qualifications to export hazardous chemicals?
Yes. We hold a valid license for the operation of hazardous chemicals and are well-versed in the export declaration, packaging, documentation, and transportation requirements for various types of hazardous goods. We are capable of handling the export of Class 3, Class 5, Class 8, and Class 9 hazardous chemicals.


4. What are the company's main products?
Our core product portfolio includes:
Plastic resins: PP, PE, PVC, ABS, PC, POM, etc.
Basic chemical raw materials: Soda ash, caustic soda, titanium dioxide, methanol, styrene, ethylene glycol, PTA, etc.
Fine chemicals: Pharmaceutical intermediates, pesticide intermediates, chemical additives, solvents, surfactants.
Chemical fiber raw materials: Polyester filament, polyester staple fiber, polyester chips (PET).
Inorganic chemicals: Calcium carbonate, talc powder, sodium sulfate, calcium chloride, magnesium chloride, etc.
Others: Paraffin wax, white oil, petroleum jelly (Vaseline), rubber, water treatment chemicals, etc.
If you have specific product requirements, please feel free to contact us; we will quickly source high-quality products to meet your needs.


5. How can I obtain a product quote? What information is required?
You can contact us via our official website, by phone, or by email. To ensure a quick and accurate quote, please provide the following details: product name and specifications, target purchase quantity, destination port, and desired delivery time. Please also inform us of any special packaging or testing requirements.

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