5-Bromo-2-chloropyrimidine CAS#32779-36-5

5-Bromo-2-chloropyrimidine CAS#32779-36-5

Basic Information

Valuable Pharmaceutical Intermediate: Widely used in the synthesis of macitentan, an endothelin receptor antagonist for pulmonary hypertension treatment.


Reactive Halogenated Structure: Contains both chloro and bromo substituents, enabling versatile chemical transformations and functionalization.


High Synthetic Utility: The pyrimidine core structure supports efficient incorporation into complex drug molecules.


Supports Advanced Drug Development: Facilitates the production of targeted therapeutic agents, making it important for modern pharmaceutical research.


Can't Find The Product You Need?

Tell Us Your Product Requirements, Specifications And Target Industry, Our Professional Team Will Reply You Within 24 Hours.

Contact us

Products Center

product description

Product Description of 5-Bromo-2-chloropyrimidine CAS#32779-36-5

5-Bromo-2-chloropyrimidine is a halogenated pyrimidine derivative featuring chloro and bromo substituents at the 2- and 5-positions of the ring. It is primarily used as a pharmaceutical intermediate in the synthesis of macitentan, an endothelin receptor antagonist employed in the treatment of pulmonary hypertension.


Product Applications of 5-Bromo-2-chloropyrimidine CAS#32779-36-5

5-Bromo-2-chloropyrimidine is used as a pharmaceutical intermediate in the synthesis of various drug compounds, including inhibitors. It is also utilized in cross-coupling reactions involving indium organometallic reagents with 2,5-dihalopyrimidines.


Products Center

Product Information

Parameters


Melting point73-79 °C (lit.)
Boiling point95°C 15mm
density1.859±0.06 g/cm3(Predicted)
Fp95°C/15mm
storage temp.Keep in dark place,Sealed in dry,Room Temperature
solubilitysoluble in Methanol
pka-2.84±0.22(Predicted)
formCrystalline Powder
colorOff-white to beige
Water Solubilityinsoluble
BRN507955
Stability:Hygroscopic
InChIInChI=1S/C4H2BrClN2/c5-3-1-7-4(6)8-2-3/h1-2H
InChIKeyXPGIBDJXEVAVTO-UHFFFAOYSA-N
SMILESC1(Cl)=NC=C(Br)C=N1
CAS DataBase Reference32779-36-5(CAS DataBase Reference)
Hazard CodesXi
Risk Statements36/37/38
Safety Statements26-36/39-37/39-36
RIDADRUN 3335
WGK Germany3
HazardClassIRRITANT
HS Code29335990


Products Center

Factory Showcase

拼图_美图设计室-(1)

Products Center

Shipping And Transportation

拼图_美图设计室

Products Center

FAQ

1. What kind of company is Bohai New Materials?
Bohai New Materials (Tianjin) Co., Ltd. is a foreign trade company specializing in the international trade of chemical products, located in the Binhai New Area of ​​Tianjin. Leveraging the strategic location of Tianjin Port, the company provides one-stop procurement and export services to global clients for a wide range of products, including plastic resins, basic chemical raw materials, fine chemicals, chemical fiber raw materials, and inorganic chemicals.


2. Which markets does the company serve?
Our products are primarily exported to Southeast Asia (Vietnam, Thailand, Indonesia, Malaysia), the Middle East (UAE, Saudi Arabia), Africa (Nigeria, Kenya), as well as Europe and the Americas.


3. Does the company have the qualifications to export hazardous chemicals?
Yes. We hold a valid license for the operation of hazardous chemicals and are well-versed in the export declaration, packaging, documentation, and transportation requirements for various types of hazardous goods. We are capable of handling the export of Class 3, Class 5, Class 8, and Class 9 hazardous chemicals.


4. What are the company's main products?
Our core product portfolio includes:
Plastic resins: PP, PE, PVC, ABS, PC, POM, etc.
Basic chemical raw materials: Soda ash, caustic soda, titanium dioxide, methanol, styrene, ethylene glycol, PTA, etc.
Fine chemicals: Pharmaceutical intermediates, pesticide intermediates, chemical additives, solvents, surfactants.
Chemical fiber raw materials: Polyester filament, polyester staple fiber, polyester chips (PET).
Inorganic chemicals: Calcium carbonate, talc powder, sodium sulfate, calcium chloride, magnesium chloride, etc.
Others: Paraffin wax, white oil, petroleum jelly (Vaseline), rubber, water treatment chemicals, etc.
If you have specific product requirements, please feel free to contact us; we will quickly source high-quality products to meet your needs.


5. How can I obtain a product quote? What information is required?
You can contact us via our official website, by phone, or by email. To ensure a quick and accurate quote, please provide the following details: product name and specifications, target purchase quantity, destination port, and desired delivery time. Please also inform us of any special packaging or testing requirements.

Products Center

Contact Us

Submit

Products Center

Recommendation